It is native to South America, where it can be found in Brazil, southeastern Colombia, Ecuador, French Guiana, and Peru.

[2][3][4][1] R. ventrimaculata secretes poison through glands in the skin which protect it from fungi and bacteria as well as from predators, which are also warned to stay clear by the aposematic coloration.

Metamorphosis into a frog is complete after 60 to 80 days; at which point they become independent of their parents but tend to remain in close proximity.

This diurnal frog lives in the Amazon, specifically in primary rainforests that have deep leaf litter and thick understory.

[1] The frog's range includes protected parks, such as Parque Nacional Yasuní, Comunidad Sarayaku, Estación de Biodiversidad Tiputini, and Reserva Comunal Tamshiyacu Tahuayo.