It can easily be confused with retinal detachment by the non-expert observer and in difficult cases even the expert may have difficulty differentiating the two.

Unfortunately one still sees cases of uncomplicated retinoschisis treated by laser retinopexy or cryopexy in an attempt to stop its progression towards the macula.

There is always vision loss in the region of the schisis as the sensory retina is separated from the ganglion layer.

If the retinoschisis involves the macula, then the high-resolution central area of vision used to view detail is lost, and this is one form of macular disease.

Individuals affected by XLRS are at an increased risk for retinal detachment and eye hemorrhage, among other potential complications.

Retinoschisis causes acuity loss in the center of the visual field through the formation of tiny cysts in the retina, often forming a "spoke-wheel" pattern that can be very subtle.

Males diagnosed with X-linked juvenile retinoschisis and females who are suspected carriers may be eligible to participate.

[6] The diagnosis of the disease is usually made during an examination of the back of the eye (fundus) where any splits, tears or rips may be seen.

One diagnostic tool is optical coherence tomography (OCT), which uses light waves to create images of the retina and based on ophthalmoscopy with scleral depression and contact lens examination.

[7] After 1 year, the paper concluded that the therapy "was generally safe and well tolerated but failed to demonstrate a measurable treatment effect" and a 5-year follow up will be conducted to assess long-term safety.