It stars an ensemble cast of Jennifer Tilly, María Conchita Alonso, Ione Skye, Debi Mazar, Laura Harring, and Tippi Hedren.

Photographed with a hand-cranked camera and scored with music of the roaring twenties, this silent film strings together the lives of the most famous and infamous stars of the 1920s, including Rudolph Valentino, Gloria Swanson, Clara Bow, Lupe Vélez, Fatty Arbuckle, and William Desmond Taylor.

Return to Babylon features locations in and around Hollywood, California, including the original home of Rudolph Valentino, Falcon Lair, as well as the Norma Talmadge estate, the Canfield-Moreno Estate, and the Magic Castle in the Hollywood Hills.

Media releases and interviews stated that the actors faces can be seen "morphing" into grotesque shapes in certain shots.

Many of the cast and crew had confirmed many of these reports and stated they experienced odd events during production, with Jennifer Tilly in particular describing feeling "watched" and "touched" by unseen forces during filming.