Produced by the New York office of the series' distributor, ITC Entertainment, the film is a compilation of the Captain Scarlet episodes "Shadow of Fear", "Lunarville 7", "Crater 101" and "Dangerous Rendezvous".

[1] Set in 2068, the original series depicts a "war of nerves" between Earth and the Mysterons: a race of Martians with the power to create functioning copies of destroyed people or objects and use them to carry out acts of aggression against humanity.

Earth is defended by a military organisation called Spectrum, whose top agent, Captain Scarlet, was killed by the Mysterons and replaced by a reconstruction that subsequently broke free of their control.

Created by the New York office of ITC Entertainment, Revenge of the Mysterons from Mars was one of several TV film re-workings of Anderson series designed to renew overseas interest in these productions and promote syndication sales in the United States.

[5] On 24 November 1988 (Thanksgiving in the United States), the film was televised as the second episode of the original version of the movie-mocking comedy series Mystery Science Theater 3000, broadcast by Minneapolis TV station KTMA.