It follows two students at a prestigious all-female school: Hina, an aspiring writer who has a fear of men, and Kaede, a man who disguises himself as a woman to hide from his grandfather, who intends to stop him from becoming an actor.

[6] Reverse X Rebirth was written and illustrated by Shinobu Amano [ja], and was originally conceived prior to her earlier series Last Game (2011) as a story about a girl who is nervous around her cross-dressing roommate, not realizing that he is not a woman.

[5] When eventually returning to the idea, Amano wanted to portray people from different walks of life with different viewpoints, while writing Yuri as similar to herself, and wrote the series from the perspective of an all-seeing narrator to allow readers to follow what happens with both Kaede and Hina.

[11] Reverse X Rebirth was well received, including its one-shots, which was what led the publisher to pick it up for serialization;[3] Mangapedia called it one of Amano's major works, along with Last Game and Hokenshitsu no Kageyama-kun (2017).

[14] Natalie appreciated the series for showing a liberal view of gender[15] and thought that it succeeds in carefully depicting gradual emotional changes its characters go through,[5] considering it characteristic of Amano and LaLa.