Reginald (or Reyner) Wolfe (died 1573) was a Dutch-born English Protestant printer and one of the original members of the Royal Stationers' Company.
A learned and devout Protestant, he settled in England some time before 1530 and established himself as a bookseller at St. Paul's Churchyard, London.
Edward VI made him Royal Printer in Latin, Greek and Hebrew and awarded him an annuity of 26s.
He hired Raphael Holinshed and William Harrison to assist in the task, but it remained unfinished at Wolfe's death in 1573.
Wolfe married Joan (died 1574), who briefly ran his business after his death.