The Reynolds Building is a 314-foot (96 m) Art Deco skyscraper at 51 East 4th Street in Winston-Salem, North Carolina.

[5] In March 2016, The Residences @ the R.J. Reynolds Building, apartments located on the top 11 floors, opened.

[7] When completed for $2.7 million ($36.3 million in 2016 dollars)[6] as the headquarters of R. J. Reynolds Tobacco Company, it was the tallest building between Baltimore, Maryland, Birmingham, Alabama, and the Miami-Dade County Courthouse, and it won a national architecture award.

[13] Shreve & Lamb, the architects, were asked for "an effect of conservatism along with attractiveness, but to avoid flashiness."

[13] Most of the offices were occupied by organizations related to the tobacco industry, such as railroads, insurance companies, and attorneys.

[15] In March 2013, Reynolds American selected CBRE to market the building, which the company intended to sell for $15 million.

The $60 million in renovations included the lobby that would look familiar to those who worked in the building decades ago, described this way in an article by Robert Lopez that appeared on the Winston-Salem Journal web site.

Straight ahead from the main entrance is the elevator bank, gold and silver leaf ceiling overhead, and brass doors polished to a blinding finish.

An octagonal hall just past the elevators is clad is [sic] St. Genevieve golden vein marble.