[3] Reynoldsville was originally called Winslow Township and was renamed after local postmaster Thomas Reynolds in 1850.

[5] Reynoldsville would grow its industries in the way of silk mills, brick and tile works, a tannery, a macaroni factory, and an asbestos plant to provide employment.

The borough was greatly enlarged in 1913 when it annexed West Reynoldsville (population 993 in 1910) and three large adjacent areas.

The Herpel Brothers Foundry and Machine Shop was added to the National Register of Historic Places in 2004.

[6] Reynoldsville is located in eastern Jefferson County at 41°5′40″N 78°53′15″W / 41.09444°N 78.88750°W / 41.09444; -78.88750 (41.094465, -78.887604),[7] in the valley of Sandy Lick Creek where it is joined by Soldier Run.

Pennsylvania Route 950 runs northeast from Reynoldsville up the Sandy Lick Creek valley 6 miles (10 km) to Falls Creek, and Pennsylvania Route 310 leads south 12 miles (19 km) to Punxsutawney.

Jefferson County - DuBois AVTS (also known as Jeff Tech) is located in Reynoldsville, PA.