Ribeira Grande (also: Povoação) is the largest town of the Ribeira Grande Municipality on the island of Santo Antão, Cape Verde.

It is situated in the northeastern part of the island, near the outflow of the river Ribeira Grande and its tributary Ribeira da Torre into the Atlantic Ocean.

The main settlement was Ribeira Grande, which became the seat of the municipality of Santo Antão in 1732.

[3] Its earlier buildings are built with Portuguese colonial architecture.

Notable people includes chemist Roberto Duarte Silva, poet Manuel de Novas, and José Luís Jesus, former foreign minister and president of the International Tribunal for the Law of the Sea.