He won one singles tournament (Delray Beach in 2004) and reached the semifinals three times at the Brasil Open.

Mello won his lone ATP title at Delray Beach, defeating Vincent Spadea in the final.

One of his first major feats was qualifying for the main singles draw in the Australian Open that year, his first participation in a Grand Slam tournament; he lost to #8 seed David Nalbandian in the first round.

At the Campbell's Hall of Fame Championships, Mello played top seed Andy Murray.

At the RCA Championships in Indianapolis, Mello faced Jean-René Lisnard in the first round and won in straight sets.