[8] Tisci, under Givenchy, designed the costumes for Madonna's Sticky & Sweet Tour in 2008, following Jean Paul Gaultier and Dolce & Gabbana.

[citation needed] In February 2017 Tisci stepped down as creative director of Givenchy, "I now wish to focus on my personal interests and passions.

[13] His tenure lasted through to September 2022, when it was announced that Tisci would be replaced at the helm of Burberry's creative efforts by English designer Daniel Lee.

[15] For the Givenchy Fall-Winter 2010 collection,[16] he included a new model, Lea T, a transgender woman from Brazil, his longtime personal assistant.

[citation needed] Throughout his career, Tisci's numerous connections and relationships have enabled him to collaborate with well-known artists on various projects: In addition to his position at Givenchy, Tisci has collaborated with the choreographers Sidi Larbi Cherkaoui and Damien Jalet on the costume design of the orchestral ballet Boléro by Maurice Ravel at the Opéra Garnier.

Italian model Mariacarla Boscono often appears in his runway shows and ad campaigns, owing possibly to the fact that Tisci has had a friendship with her since before his days at Givenchy.