Thompson spent most of his 12-year career playing in Minor League Baseball, and retired in 2013 after a foot and head injury.

He attended James Madison University in Harrisonburg, Virginia, where he played baseball for the Dukes under head coach Spanky McFarland.

He arrived on JMU's campus in the Fall of 1997 and spent the next three years compiling some of the best baseball statistics in the program's history.

[1][2][3] In 2000, Thompson was also named Second Team All-CAA, JMU's Most Valuable Player and was also a Virginia Sports Information Directors All State Honorable Mention.

The Toronto Blue Jays traded Thompson to the Pittsburgh Pirates in July 2003 for pitcher John Wasdin.

[6] Thompson made his major league debut for the Kansas City Royals in April 2004 as a Rule 5 Draft pick who mainly entered games to pinch-run.

His only at-bat was April 20, 2004 against catcher Tim Laker, who was only pitching because the Royals led 15-5, and resulted in the speedy Thompson grounding into a double play.

Thompson signed a minor league contract with the Boston Red Sox in January 2008, but was released in April before playing a game in the organization.

Thompson recorded his first major league hit on May 17, 2012 off Boston Red Sox pitcher Felix Doubront.