[1] He briefly taught at a Los Angeles high school before landing his first major television role, that of Dr. Marcus Hunter on the soap opera Days of Our Lives.

[1] He frequently used his celebrity status to raise money for the Aliso Academy,[2] a private school in Rancho Santa Margarita, California that serves deaf children.

[5][6] He appeared as Dr. Stephen Franklin on the well-regarded science fiction series Babylon 5 (1994–1998), reprising the role in the final aired episode of the spin-off show, Crusade ("Each Night I Dream of Home").

[3] His final television appearance was as a guest star on a 2004 episode of the Nickelodeon series Drake & Josh, entitled "The Gary Grill" portraying an FBI agent, which was dedicated to his memory.

[1][12] Biggs collapsed at his home in Los Angeles, and died at Providence Saint Joseph Medical Center of complications stemming from aortic dissection on May 22, 2004.