Andrews earned a Bachelor of Arts degree from Haverford College in 1977 and a Juris Doctor from the University of California, Berkeley School of Law in 1981.

[1] From 1981 until 1982, Andrews served as a law clerk for Judge Collins J. Seitz on the United States Court of Appeals for the Third Circuit.

[1][2] From 1983 until 2006, Andrews worked as an assistant United States attorney for the District of Delaware.

[1][2] On May 11, 2011, President Barack Obama nominated Andrews to a seat on the United States District Court for the District of Delaware, to fill the vacancy created when Judge Joseph James Farnan Jr. retired on July 31, 2010.

On November 3, 2011, the Senate confirmed Andrews by unanimous consent.