His credits include the film Rocky V (1990), where he played the Don King-esque George Washington Duke;[2][3][4] Hostetler in Deadwood (2004–2006); and Owen in Men of a Certain Age (2009–2012).

He has also appeared in a 1989 episode of Miami Vice, as Battlin’ Barry Gay; as a possessed coroner in Jason Goes to Hell: The Final Friday (1993); and in the films and TV shows Deadwood, The Big Lebowski, Babylon 5, Special Unit 2, L.A. Law, NYPD Blue, Living Single, Posse, Seinfeld, Friends, How I Met Your Mother, Men Don't Tell, and Charmed.

He has also appeared in Nutty Professor II: The Klumps and Bean: The Ultimate Disaster Movie, as well as reporter Charles Parker in the cult classic adaptation of Colin Bateman’s Divorcing Jack.

He had a minor role as a senior naval officer in Roland Emmerich's Godzilla.

Gant joined General Hospital on February 6, 2007 in the role of Dr. Russell Ford.