[2] His research informs innovative clinical trial designs with signal-seeking biomarkers to monitor therapy responses and optimise patient treatment.

[2] His research also highlights the importance of combining sunscreen with other sun avoidance strategies to reduce population melanoma risk.

He was amongst the first to show that mitogen activated protein kinases regulate gene expression by directly phosphorylating transcription factors.

In collaboration with David Barford, he solved the crystal structure of B-RAF and explained how it is activated by mutations that occur in cancer.

He is now translating these studies to the clinic by leading a large effort to design and synthesize new anti-B-RAF drugs that will be used to treat melanoma.