In 1578, he was prebendary at Brecon collegiate church and the rector of Barton, Pembrokeshire; in the following year, he became vicar of his native Llanafan Fawr in Brecknockshire and in 1580 the rector of Nangle, Pembrokeshire, and prebendary of St David's Cathedral, where his father's first cousin, Richard Davies, was bishop.
[citation needed] In the same year as his marriage he was appointed chaplain to Sir John Perrot, Lord Deputy of Ireland and Dean of St Patrick's Cathedral, Dublin.
His support for Perrot led to his imprisonment in the Fleet Prison and an appearance before the Star Chamber, leading to a fine of £2,000 (later remitted in return for an annual payment to the queen of 300 marks for 10 years).
[2][3] Their younger son, Sir Thomas Meredith (died 1677), was the Member of Parliament for Old Leighlin, Co. Carlow, and ancestor of the Baronets of Dollardstown, Newtown and Carlandstown, Co. Meath.
A large monument in black and White marble stands in the North Transept of St. Patrick's Cathedral to Bishop Meredith.