Since 1969, he has decorated the sets designed by Patrice Chéreau, and together they have put on several dramatic texts by Bernard-Marie Koltès.
In the theatre, they participated in the centennial productions of Wagner's Der Ring des Nibelungen at the Bayreuth Festival conducted by Pierre Boulez.
For the Opéra National de Paris, they presented Alban Berg's Lulu, and Offenbach's The Tales of Hoffmann, and for the La Scala, Milan, they collaborated on Wagner's Tristan und Isolde (2007).
Peduzzi also created films with Chéreau, such as La Reine Margot and Ceux qui m'aiment prendront le train.
Peduzzi's sets are often formed of large vertical masses symbolising the dangers that threaten the characters.