[4] However, it was stopped when he suffered a knee injury on a one-yard Corey Dillon touchdown run against the San Diego Chargers in October 2005.

A housing and consumer economics major, Seymour was a four-year letterman at Georgia who played in 41 games for the Bulldogs, starting 25.

He also appeared in every game in 1998 as a sophomore and made 4 starts, finishing fourth on the team with 69 tackles (32 solos), 4 sacks and 14 quarterback pressures.

In that contest he collected six tackles (5 solos), including a pair of sacks, three stops for minus 12 yards and a pressure that resulted in an interception in a 24–6 victory.

Seymour also had a presence on special teams, blocking field goals in back-to-back November games against the Oakland Raiders and Minnesota Vikings.

While the Patriots did not fulfill Seymour's request, they did give him a pay raise for the 2005 season in order to end his holdout.

[8] Seymour's 2005 season began with the defensive end recording two sacks and averaging more than five tackles in the first four games before suffering a left knee injury playing fullback in a goal line situation against the San Diego Chargers in Week 4.

Seymour finished the season with four sacks and 46 tackles, and was named to his third-consecutive first-team All-Pro team as well as his fourth consecutive Pro Bowl, but did not play due to injury.

Seymour was fined $7,500 by the NFL for stepping on Indianapolis Colts offensive tackle Tarik Glenn during a November 5, 2006, game.

[11] Seymour, who also had a groin injury and admitted he was not 100 percent,[12] tallied four sacks, 40 tackles, and a blocked field goal on the season.

In the 2007 offseason, Seymour had surgery on the left knee he had originally injured more than two years prior, an injury he said had hampered his conditioning and play during the 2005 and 2006 seasons.

[15] Seymour was activated from the PUP on October 27,[16] and played the balance of the regular season and the playoffs, including Super Bowl XLII, a loss to the New York Giants.

[17] Recording 23 tackles and 1.5 sacks, Seymour was not named to the Pro Bowl or the All-Pro team for the first time since his rookie season.

[20] The Boston Herald, Boston Globe, and National Football Post all claimed that on or before September 10, the Raiders sent Seymour a formal letter ordering him to report within five days or risk being placed on the reserve/left squad list, which would prevent him from playing for any team in 2009, and thus would prevent him from achieving free agency until he played out his contract in 2010.

Seymour said there were "personal issues" concerning his family and that an NFLPA grievance filed on his behalf, which claimed the Raiders were not allowed to send him a five-day letter, was a "procedural thing.

[33] On February 17, 2011, Seymour agreed to a two-year, $30 million contract extension, making him the highest paid defensive player in the NFL.

[36] On November 2, Seymour was fined $15,750 for hitting his former teammate, Kansas City Chiefs quarterback Matt Cassel.

The contract stipulated if Seymour did not meet a certain amount of allotted playing time the Raiders would have the option of voiding the final year of the deal.