The college remained there until the merger with Cuddesdon in 1975, when the site, renamed Foxcombe Hall, became the regional headquarters of the Open University.

In 2005, the Oxford Centre for Ecclesiology and Practical Theology (OxCEPT) was founded, which provides research and consultancy services to the wider church.

In 2010 the college launched a £10 million appeal to build a new education centre and chapel, as well as to raise funds for endowing bursaries, fellowships, studentships and research.

Harriet Monsell House also included an enclosure for a community of five Anglican sisters who had moved from their base at Begbroke Priory.

The college developed a programme of Christian–Muslim dialogue and related work, including a Visiting Fellowship for Islamic Scholars established at Cuddesdon in partnership with the Dubai-based Al Maktoum Institute.

Men and women with a range of previous experience, not necessarily graduates, take a two or three-year course of study incorporating pastoral and academic training.

The college has recently been awarded Innovation funding to establish courses to train Children's Youth and Families Ministers alongside the current ordinand and reader students.

In August 2014, two ordinands, Shemil Mathew (who later became an associate lecturer) and Joseph Fernandas, partnered with the support of the college to organize a significant conference titled "One Body, Many Parts."

Since then, AMEN has flourished to become the Church of England's largest independent network of its kind, consisting of individuals from UK Minority Ethnic and Global Majority heritage.

The network is dedicated to promoting inclusivity, representation, and active engagement of Minority Ethnic people at all levels within the church.

In 2012 the college became the new home of the Sisters of the Community of St John Baptist and the Community of the Companions of Jesus the Good Shepherd as part of a major building programme to provide more teaching and residential accommodation, named after Harriet Monsell, founder of CSJB, as well as a new chapel named in honour of Bishop Edward King, sometime principal of Cuddesdon.

It also collaborates with the Bible Reading Fellowship for an annual Festival of Prayer The College is home to the Bishop Edward King Chapel.

The Chapel has a lattice-work timber frame which comprises curved laminated columns and beams to support a 13m high roof.