[2] Despite its size, the river is well known for fishing, especially for spring salmon, sea trout and char, with the season running from 1 March to 30 September.

On the north-eastern edge of Donegal Town, the Drumenny Burn flows into the River Eske beside the Community Hospital.

The mouth of the river is directly opposite a former Franciscan Abbey which was built by the O'Donnells but was destroyed by the English following the Flight of the Earls in 1607.

[citation needed] Almost as soon as the river parts from Lough Eske, it is crossed by Lough Eske Bridge; the river then flows in a southwest direction towards Donegal Town with the next crossing some two kilometres (1.2 miles) down stream at what is called Thrushbank Bridge; it continues southwestwards and is crossed by the N56 section of the Donegal Town By-pass by a new concrete bridge.

From this new bridge it heads southwards, were the smaller Drumenny Burn joins it at a spot between the Community Hospital and The Northern Garage.