The current facility opened on March 31, 1998, but for the greatest part of its history the hospital was located at 9851 Magnolia Avenue in Riverside.

While at that location, and operating under the name Riverside General Hospital University Medical Center, two nationally followed patient stories developed.

In September, 1896, the Riverside County Board of Supervisors purchased the Palma Hotel in San Jacinto, and moved the hospital to that location.

On December 25, 1899, an earthquake destroyed the newly built brick hospital and patients were relocated to the Arlington Hotel in downtown Riverside.

While the influenza epidemic swept through Riverside in 1918, the hospital set a record of 115 patients in just one day, on November 1.

1930s The Great Depression hit the country hard; tax revenue dropped and patient load skyrocketed.

Federal Works Progress Administration funds enabled Riverside County to add some much needed larger buildings for the hospital.

Population growth in Riverside County and a steady increase in patient census necessitated planning for a new, larger facility.

The Landers earthquake in 1992 rendered some hospital buildings structurally unsafe, and design of the new facility in Moreno Valley began.

The 21st Century In August 2004, Riverside County leased a newly built “Annex,” located across campus from RUHS-MC.