The Santa Clara–Caibarién Road (4–321), also known as the Road of Camajuaní is a Cuban state highway connecting the cities of Santa Clara to Caibarién.

It starts at a roundabout with the Avenida Liberacion and the Santa Clara Beltway in Santa Clara, to continues east through the settlements of Minagric, Los Moros, La Granjita, El Gigante, the University of Las Villas, Camilo Cienfuegos, Los Güiros, Los Paragüitas, El Amparo, El Berro, Crucero Carmita, Blanquizal, Tarafa, Monte de la Coja, Camajuaní, El Níspero, Entronque de Vueltas, Muelas Quietas, Taguayabón, Aguanó, El Chalet, Remedios, Marcelo Salado, and finally reaches Caibarién.

[1] In June 2024, in Crucero Carmita on the 4–321, a tourist Transgaviota bus, coming from Cayo Santa María to the Abel Santamaría Airport, and a privately owned car crashed into each other, with 26 injuries and 1 death, with it being suggested the car went into the left lane, which is common in the region.

[2][3][4] Also in June 2024, residents living nearby the road, in the Santa Clara-Camajuani area, protests and blocked the road due to lack of drinking water in the region for 50 days.

[6] Sources say over 3,500 people living in neighborhoods around the road have been affected in an over 68 day period.