Roanoke is a city in Randolph County, which is in the Piedmont region of eastern Alabama, United States.

Roanoke was occupied by the Creek before treaties to persuade the Native Americans to cede their land, followed by forced migration under the Indian Removal Act of 1830.

Initially called High Pine in the 1830s after a nearby creek, it was allegedly burned during an Indian uprising in 1836.

Alabama State Route 22 also runs through the city, leading west 13 mi (21 km) to Wadley and northeast 9 mi (14 km) to the Georgia state line.

On December 1, 2011, the Handley High Tigers won the AHSAA Football Class 3A State Championship.

In 2016 and 2020 the Handley High Tigers won the AHSAA 4A state title.

[5] At the 2000 census there were 6,563 people in 2,467 households, including 1,660 families, in the city.

There were 2,792 housing units at an average density of 148.4 per square mile (57.3/km2).

At the 2010 census there were 6,074 people in 2,409 households, including 1,538 families, in the city.

As of the 2020 United States census, there were 5,311 people, 2,387 households, and 1,562 families residing in the city.