Known as a stay-at-home defenseman, he played in 783 career regular season games for the Pittsburgh Penguins, Los Angeles Kings and the Chicago Blackhawks.

Additionally, on October 4, 2008, Scuderi ended a 120-game scoreless streak in Stockholm against the Ottawa Senators, when he scored a tying goal to get the Penguins into an overtime situation; they later won the game.

On April 19, 2009, Scuderi recorded his first career Stanley Cup playoff goal against the Philadelphia Flyers in Game 3 of the Eastern Conference Quarter-finals.

[6] Within weeks of winning the Cup, Scuderi hit the market as an unrestricted free agent, as the Penguins could not afford him under the salary cap.

He took a hit early in the first period, which resulted in a five-minute major penalty and three subsequent powerplay goals for the Kings, leading them to their first ever Stanley Cup.

[10] Scuderi crashed into the boards as a result of a legal hit by David Clarkson of the Toronto Maple Leafs on October 26, 2013, in a 4–1 defeat.

In the 2015–16 season, Scuderi provided 4 assists in 25 games for the Penguins before he was traded to the Chicago Blackhawks in exchange for fellow defenseman Trevor Daley on December 14, 2015.