Soon afterwards, he moved to Los Angeles to pursue acting, but faced difficulty in finding roles, other than small parts in films and television advertisements.

Following the release of Red Dead Redemption, Wiethoff moved back to Seymour to focus on his family, marrying his wife Tayler, with whom he has two children.

He briefly returned to acting in New York City for Undead Nightmare, the downloadable content pack for Red Dead Redemption, but remained in Seymour afterwards to work in construction, allowing him to spend time with his family.

In 2014, Wiethoff returned to portray John Marston in Red Dead Redemption 2, a prequel to the original game.

[8] Wiethoff attended Seymour High School,[9] and graduated from Indiana University Bloomington with a degree in general studies in 1999.

He visited there for a week and was convinced by many people that they could get him acting roles in films, and he moved shortly after; though he did not take the offers seriously, he felt that it would be more enjoyable than working construction in Indiana.

[12] The recording crew often referred to scenes from Rockstar's Grand Theft Auto IV (2008) during production; Wiethoff pretended to understand before eventually admitting that he had not played the game.

[10] For his role in Red Dead Redemption, Wiethoff won Outstanding Character Performance at the 14th Annual Interactive Achievement Awards.

[10] About a month after moving back, he was asked to return for the downloadable content Undead Nightmare (2010), which was recorded in New York City, instead of Los Angeles.

[21] After the game's release, Wiethoff turned his chicken coop into a home office filled with art and gifts he has received from fans, several of which he has garnered from the conventions that he attends.