[2] Wynne's early drawings and collages were influenced by the Fluxus movement via Ray Johnson, a seminal figure of Neo-Dada and founder of the New York Correspondence School.

[5][3] The participants included Anaïs Nin, Marian Seldes, Leo Lerman, Michael Wager, Novella Nelson, Osceola Adams, Owen Dodson, Wyatt Emory Cooper, Peggy Cass, Ruth Ford, Earle Hyman.

[7][8] In 1976, he scored Joan Jonas's I Want to Live in the Country (And Other Romances), counterbalancing her visuals and readings from her journal with music evoking open spaces.

[9][10] Wynne's use of industrial materials in his work, such as his Xerox art,[3] was a part of his first installation, Sphere Redux, at The Kitchen in New York City, in 1981.

[11] In the 1990s, Wynne's exhibitions of paintings, sculptures, and prints at the Holly Solomon Gallery became installations;[12] his works set against wallpaper with images from the opera La Sonnambula (Bellini)[13] or The Flies (Sartre).

[16] Barbara A. MacAdam from the Brooklyn Rail described Wynne's installations, "The objects of the gallery—the artifacts, paintings, sculpture, and furniture are reflected upon by the artist, literally and figuratively, and become a part of his, and our, stream of consciousness.