DiPierdomenico won the Brownlow Medal, in 1986 tying with Greg Williams, who was playing for Sydney at the time.

[5] Late in the first quarter of the 1989 VFL Grand Final, DiPierdomenico was running backwards to take a mark when he was met solidly from behind by Geelong star Gary Ablett.

[6] He collapsed shortly after the game and was rushed to the casualty ward of St. Vincent's Hospital, where doctors found out that DiPierdomenico had punctured a lung.

"[7]DiPierdomenico went on to play 240 games and kick 130 goals with the Hawks, retiring in 1991, and participating in five day and four night premierships during one of the most successful eras that a VFL/AFL club has ever achieved.

In 2010, he was stood down from his role in the Auskick junior development program after making a racist remark regarding Gavin Wanganeen.

[9] DiPierdomenico made a cameo in the TV series Neighbours in 1999, and he appeared on the Channel 9 weight-loss show Excess Baggage in 2012.

DiPierdomenico is an advocate for incontinence awareness, taking a brave step to publicly bring attention to the taboo subject.