During the English Civil War, during which he attempted to remain neutral, he served as master of the free school at Gillingham, Dorset, and was privately ordained by Robert Skinner, bishop of Oxford.

Returning to London in 1671, he was appointed Preacher of the Rolls Chapel and chaplain to the Lord Keeper.

His preaching against Roman Catholicism incurred the king's displeasure, as did Frampton's decision not to instal the candidate of the Catholic President of Magdalen College, Oxford, to the living of Slimbridge.

An opponent of James's Declaration of Indulgence in 1688, Frampton was to join Archbishop William Sancroft's delegation that petitioned the king to revoke the Indulgence, but a delay in travel prevented him from being numbered among the Seven Bishops imprisoned in the Tower of London.

He died at his home at Standish on 25 May 1708, being buried on the north side of the altar in the parish church.