[4] When the Whigs came to power in November 1830 under Lord Grey, Grosvenor was appointed Comptroller of the Household and admitted to the Privy Council.

However, when the Whigs returned to office in 1846 under Lord John Russell he was made Treasurer of the Household,[6] which he remained until his resignation in July 1847.

[9] Apart from his political career, Lord Ebury was an active campaigner for Protestantism in the Church of England and was the founder and President of the society for the "revision of the prayer-book".

He was also involved in the movement led by Anthony Ashley Cooper, 7th Earl of Shaftesbury, for the improvement of factory working hours.

Lord Ebury was also a fervent supporter of homeopathy, the medical doctrine introduced by the German physician Samuel Hahnemann.

Lord Ebury served as chairman and president of the London Homoeopathic Hospital from its foundation in 1849, and during that time even defended the doctrine and the institution against its opponents in Parliament.