He evokes his paternal roots in his 2006 film Le Voyage en Armenie.

Guédiguian became concerned with political questions and for a while was involved with the French Communist Party.

Like Marcel Pagnol and René Allio before him, he anchors his films in social reality.

[1][2] He has been married to actress Ariane Ascaride since 1975 and they have two daughters, Valentine and Madeleine.

[3] In December 2023, alongside 50 other filmmakers, Guédiguian signed an open letter published in Libération demanding a ceasefire and an end to the killing of civilians amid the 2023 Israeli invasion of the Gaza Strip, and for a humanitarian corridor into Gaza to be established for humanitarian aid, and the release of hostages.