He played college football for the Tennessee Volunteers, earning first-team All-American honors in 2006.

[2] He won a national basketball title in the summer after eighth grade with his AAU team, the Tulsa Jammers.

[5] He was part of a heralded recruiting class with receivers Jayson Swain and Bret Smith.

He returned to play in all 13 games (no starts) and led the team with 459 yards on 25 catches (18.4 average) and four touchdowns.

Meachem appeared in all 11 games in 2005, with two starts, and again led the team in receiving yards with 383 on 29 catches (13.2 average) and two touchdowns.

Along with David Cutcliffe's return to Tennessee as offensive coordinator in 2006, Meachem, Swain and quarterback Erik Ainge all turned in career seasons.

He led the team with a career-high 71 catches for a school single-season record 1,298 yards (18.3 avg) to lead the SEC, including 11 touchdowns.

[17] In week 4 against the San Francisco 49ers, Meachem got the chance to see more game time when number 1 receiver Marques Colston was sidelined with a broken thumb.

In this game, Meachem had only 2 receptions, his first a 47-yard touchdown grab, his second a 52-yard flea flicker catch with a defender draped all over him.

[26][27] He was part of the Chargers' plan to replace Pro Bowl receiver Vincent Jackson, who left the team as a free agent.

Kevin Acee of UT-San Diego called him "the worst free agent acquisition in the history of the Chargers".

[28] On September 1, 2013, the Chargers released Meachem during final roster cuts, even though they had guaranteed him $5 million for the upcoming 2013 season.

However, a few days later, he re-signed with the team, on September 3, 2014, after rookie Khairi Fortt was placed on short-term injured reserve.

The tryout was put on hold the following day as Meachem had a foot injury and didn't practice.