Renowned for his silky skills[1] and leadership qualities, Murphy also proved a versatile player, equally capable of playing in attack or in defence depending on the situation.

After spending much of the 2000 season developing his slim frame,[4] he made his debut in Round 19 against Carlton at Princes Park, gathering 13 disposals and kicking a goal in a thrilling 3-point victory.

In 2011 he had one of his best ever seasons, finishing second in the Bulldogs' best and fairest award,[7] and earning his first selection in an All-Australian team, being named on a half-back flank.

On 10 April 2016, in the final minutes of the Bulldogs three-point loss to Hawthorn, Murphy sustained a knee injury while contesting a mark in the Hawks' forward 50.

An article he wrote about playing against Steve Johnson[14] earned him a highly commended prize in the 2012 Australian Football Media Association awards.

In 2018 in collaboration with Fox Footy he released his own short weekly series called 'Bob,' where he interviewed a number of Australian icons.

[18] In November 2024, it was announced that Murphy will join ABC Radio Melbourne to host Breakfast with Sharnelle Vella from January 2025.