Over the course of a 40 - year career, Musso has produced, mixed, remixed,[4] played on, written, or contributed to over 2000 records, CDs, movie soundtracks,[5] on every continent in the world except Antarctica.
During this period, he worked with a wide variety of artists, including Stevie Wonder, Bob Dylan, Mick Jagger, the Dalai Lama, Miles Davis, Al Green, Bob Marley, Herbie Hancock, Sting, Carlos Santana, Jimi Hendrix, The Seventy Sevens, David Bowie, George Clinton, Dave Matthews, Ornette Coleman, John Zorn, Peter Gabriel, The Ramones, Iggy Pop, Blondie, Whitney Houston, Sly & Robbie, Fine Young Cannibals, Pharoah Sanders, William Burroughs, Julian Schnabel, Bootsy Collins, The Last Poets, Ozzy Osbourne and Steve Vai.
His work for Miles Davis, Jimi Hendrix, and Bob Marley were album remixes and done posthumously.
Artists who have released CDs through MuWorks include Thomas Chapin, Last Exit, Lunar Bear Ensemble, Musso himself and Machine Gun.
Beginning in 1986, Thomas Chapin and Musso led the downtown improvisational ensemble,[8] Machine Gun.