With the rise of Nazism and following an attack in the press by Hitler's minister of propaganda Joseph Goebbels in 1933 after viewing Brennendes Geheimnis (The Burning Secret), Siodmak left Germany for Paris.

Siodmak arrived in California in 1939, where he made 23 movies, many of them widely popular thrillers and crime melodramas, which critics today regard as classics of film noir.

Following the critical success of Phantom Lady, Siodmak directed Christmas Holiday (1944) with Deanna Durbin and Gene Kelly (Hans J. Salter received an Oscar nomination for best music).

Yvonne De Carlo's working-class femme fatal (a high mark in her career) completes the deadly triangle, along with Lancaster and Dan Duryea: the archetype of doomed attraction central to all Siodmak's noirs, but the one he could fully express to its nihilistic conclusion.

Siodmak immersed himself in the creative process and genuinely loved working with actors, acquiring a reputation as an actor's director for his work with many future stars, including Burt Lancaster, Ernest Borgnine, Tony Curtis, Debra Paget, Maria Schell, Mario Adorf, Ava Gardner, Olivia de Havilland, Dorothy McGuire, Yvonne de Carlo, Barbara Stanwyck, Geraldine Fitzgerald, and Ella Raines.

Those "different type" of films he had made—The Great Sinner (1949) for MGM, Time Out of Mind (1947) for Universal (which Siodmak also produced), The Whistle at Eaton Falls (1951) for Columbia Pictures (Ernest Borgnine's debut and Dorothy Gish's return to the screen)—all proved ill-suited to his noir sensibilities (although in 1952 The Crimson Pirate, despite the difficult production, was a surprising and pleasing departure—in fact, Lancaster believed it was inspiration for the tongue-in-cheek style of the James Bond films).

The five months he collaborated with Budd Schulberg on a screenplay tentatively titled A Stone in the River Hudson, an early version of On the Waterfront, was also a major disappointment for Siodmak.

[6] It was the first in a series of films critical of his homeland, during and after Hitler, which included Nachts, wenn der Teufel kam, both thriller and social artifact of Germany under Nazi rule, shot in documentary style reminiscent of Menschen am Sonntag and Whistle at Eaton Falls, and in 1960, Mein Schulfreund, an absurdist comedy, dark and strange, with Heinz Rühmann as a postal worker attempting to reunite with childhood friend Hermann Göring.

[7] Between these films, and Mein Vater, der Schauspieler in 1956, with O. W. Fischer (the West German Rock Hudson), he took a detour into Douglas Sirk territory with the sordid melodrama, Dorothea Angermann in 1959, featuring Germany's star Ruth Leuwerik.

Later the same year he left Germany for Great Britain to film The Rough and the Smooth, with Nadja Tiller and Tony Britton, yet another noir, but much meaner and gloomier than anything he had made in America (compare its downbeat ending with that of The File on Thelma Jordan).

In 1961, L'affaire Nina B, with Pierre Brasseur and Nadja Tiller (again), returned Siodmak to familiar ground in a slick, black-and-white thriller about a pay-for-hire Nazi hunter, which could be argued was the start of the many spy themed films so popular in the 1960s.

In 1962, the entertaining Escape from East Berlin, with Don Murray and Christine Kaufman, had all the characteristic style of a Siodmak thriller, but was one that he later dismissed as something he had made for "little kids in America."

From 1964 to 1965, he made a series of films with former Tarzan Lex Barker: The Shoot, The Treasure of the Aztecs, and The Pyramid of the Sun God, all taken from the western, adventure novels of Karl May.

Siodmak's return to Hollywood filmmaking in 1967 with the wide-screen western Custer of the West was another disappointment, receiving mostly negative reviews from critics and failing to generate box-office appeal.

Siodmak ended his career with a six-hour, two-part toga and chariot epic, Kampf um Rom (1968), a more campy work (perhaps intentionally) than Cobra Woman had been.