[5] It wasn't until on 16 September 2007 when he made his league debut for the club, coming on as a second-half substitute, in a 1–1 draw against Standard Liège.

[15] Having regained his first team place since returning from injury, Rosales then scored his first goal of the season, in a 2–1 win over Sint-Truiden on 24 October 2009.

[25] Upon joining club, Rosales became a direct replacement for Ronnie Stam, who left for Premier League side Wigan Athletic[26] and was presented to the media a few days later, where he was given a number fifteen shirt.

[31] On 7 December 2010, Rosales scored a goal in a 3–3 home draw against Tottenham Hotspur, for the season's UEFA Champions League, and became the first Venezuelan to do so.

[34] Though he was on the bench that saw Twente beat Ajax 3–2 in the KNVB Cup final,[35] Rosales finished his first season, making forty-five appearances and scoring two times in all competitions.

[36] Despite this, Rosales remained at the club, although he began competing with Tim Cornelisse over the right-back position[37] and started the season well when he provided a hat-trick assists, in a 5–2 win over ADO Den Haag on 18 September 2011.

[41] Following his return, Rosales regained his first team place for the remainder of the season, as he made forty-one appearances and scoring once in all competitions.

Unfortunately, in a match against Heerenveen, in the second round of the KNVB Cup, he received a red card after a second bookable offence, in a 3–0 loss, eliminating from the tournament.

At the end of the 2013–14 season, Rosales was expected to leave the club, with La Liga side Málaga keen on signing him when his contract was set to expire.

In the 2015–16 season, Rosales continued to be in the first team regular as a right-back and his performance convinced the club to start negotiation over a contract for him.

[61] It came after when he set up one of the goals for Charles, who scored a hat-trick, in a 3–1 win over Real Sociedad on 3 October 2015,[62] as well as, being linked with a move to Sevilla in the summer.

[70] He made his debut for Espanyol on 25 September 2018, playing full 90 minutes in 1–0 home victory against SD Eibar.

[71][72] On 24 July 2019, it was announced that Rosales has agreed on a two-year contract with Spanish side CD Leganés, with an option of another year.

[1] Growing up, Rosales revealed that his father was strict towards his children, especially Roberto and learns three things from him: Modesty, sacrifice and discipline.