He is known for presenting the BBC radio show The Infinite Monkey Cage with physicist Brian Cox,[1] creating Nine Lessons and Carols for Godless People, co-creating The Cosmic Shambles Network, and his stand-up comedy career.

[4] He had appeared at the Cafe Royal as part of the Edinburgh Fringe[5] show 'Rubbernecker' alongside Stephen Merchant, Jimmy Carr and Ricky Gervais in 2001.

He concluded "Let's see if I can give up stand up for longer than I gave up whisky, or if the addiction is such that I'll start busking jokes outside the Hayward Gallery by August.

In 2005, Ince began running the Book Club night at The Albany, London, where acts were encouraged to perform turns of new and experimental material.

The Book Club proved to be so successful that Ince took it on a full UK tour in 2006, the same year he won the Time Out Award for Outstanding Achievement in Comedy.

Ince started his television career as a comedy writer, working on The 11 O'Clock Show, for which he also performed as an impressionist, including an impersonation of John Peel.

In 2017, Ince co-founded the Cosmic Shambles Network with Trent Burton, an organisation that creates podcasts, documentaries and events "for people with curious minds".

[18] Ince is an atheist and supports the Rationalist Association via New Humanist magazine by organising events at the Bloomsbury Theatre and at the Hammersmith Apollo featuring scientists, musicians and comedians.

Regular contributions come from Josie Long, Chris Addison, Ricky Gervais, Richard Dawkins, Simon Singh and Philip Jeays.