At 19, he was the youngest nominee for the Bill Masterton Memorial Trophy in NHL history after he made his debut less than four months after suffering two broken legs in a serious automobile accident.

He declared himself a fan of football and the Brazilian soccer team, and has expressed interest in returning to visit his country of birth.

[9] He played as a 15-year-old with the Prince Albert Mintos of the Saskatchewan Midget AAA Hockey League where he was named the team's top defenceman.

[11] Regehr broke out following the draft, scoring 12 goals and 32 points in 1998–99,[10] and helped the Blazers reach the WHL championship where they lost to the Calgary Hitmen.

[14] Late in that season, the Calgary Flames dealt all-star forward Theoren Fleury, along with Chris Dingman, to the Avalanche for Rene Corbet, Wade Belak, a draft pick and their choice of a prospect from a list provided by Colorado.

Regehr, who was driving home from a summer trip with his elder brother Dinho (Ronald) and two female friends, was struck head-on by another vehicle that crossed into his path.

[3] Following operations to repair the damage to Regehr's legs, doctors gained optimism, but expected he would be unable to skate before the end of the year.

[18] That night, he made his NHL debut against the Ottawa Senators and was praised by his coach, Brian Sutter, for playing a mistake free game.

He overcame rib, abdominal and wrist injuries in 2002–03 to establish himself as a top defender with the team and earned a second Masterton Trophy nomination for his dedication.

[27] While he enjoyed the tour, Regehr stated that he was not interested in joining the many other NHL players who signed on with European teams during the lockout.

[31] Doctors considered Regehr fortunate, believing that a knee brace he had been wearing prevented a more severe injury that would have seen him miss up to six months.

[36] The deal was considered to be worth less than he could have gotten as an unrestricted free agent the following year, but he chose to take less to stay in a city his family enjoyed and on a team he felt was competitive.

[39] Off the ice, Regehr was named to an NHLPA committee formed in 2007 to find a replacement for ousted Executive Director Ted Saskin.

[47] After missing the playoffs in the two previous seasons and needing to clear salary cap space to sign Alex Tanguay,[48] the Flames dealt Regehr to the Buffalo Sabres on June 25, 2011.

He was sent to Buffalo, along with Aleš Kotalík and a second round selection at the 2012 NHL Entry Draft in exchange for Paul Byron and Chris Butler.

In the final year of his contract and with Buffalo out of playoff contention, he was dealt to the Los Angeles Kings on April 1, 2013, in exchange for two second round draft picks.

Shortly after the Kings reached the third round of the 2013 Stanley Cup Playoffs, Regehr and the team agreed to a two-year, $6 million contract extension.

[14] He made his first appearance with the senior team following his rookie season in the NHL, playing six games in the 2000 Men's World Ice Hockey Championships.

[59] Regehr participated in team Canada's orientation camp for the 2010 Games in the hopes of earning a second opportunity to win an Olympic medal.

[60] While in Calgary, they were active in the community, serving as honorary co-chairs of the Impact Foundation, an organization that aims to help kids deal with the challenges of growing up.