Afterward, Perdoni played professionally for three seasons in the Canadian Football League (CFL).
[3] He was a two-year starter at defensive tackle for coach Bud Carson's Georgia Tech Yellow Jackets in 1969 and 1970.
[4] Memorably, in 1969, he had ten-tackle performance in which his pass rush contributed to four interceptions in the Yellow Jackets' 6–0 upset of the Georgia Bulldogs.
[5] As a senior team captain in 1970, he was a key member of the Yellow Jackets team that compiled a 9–3 record, and had 13 tackles in the Jackets' 17–9 victory over the Texas Tech Red Raiders in the December 1970 Sun Bowl.
[4][6] Following his senior season, he was a finalist for the first annual Lombardi Award, honoring the best college lineman of the year,[2] and he was recognized as a consensus first-team All-American in 1970, when he received first-team honors from the Associated Press (AP), the America Football Coaches Association (AFCA), Central Press Association (CPA), the Football Writers Association of America (FWAA), United Press International (UPI), Football News, The Sporting News and the Walter Camp Foundation.