Rocky Mount Central City Historic District is a national historic district located at Rocky Mount, Edgecombe County and Nash County, North Carolina.

It includes a variety of industrial, commercial, residential, and institutional buildings dating from the late-19th through mid-20th centuries.

2 (1924), Union Bus Station (1951), the Railway Express Agency Building (c. 1930), Memorial Hospital (1937), Church of the Good Shepherd (1877), Atlantic Coastline Railroad Station (1903-1916), Imperial Tobacco Company Processing Plant (1903-1923), S. H. Kress and Company (c. 1913), Belk-Tyler (c. 1905, 1915, 1920, 1945), Grand Theater (c. 1912, 1930s), Manhattan Theater (c. 1935), Holy Hope Episcopal Church (1910s), and Summerlin House (1895).

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