Rodengo-Saiano (Brescian: Rodéngh-Saià) is a comune in the province of Brescia, in Lombardy.

A center of the Franciacorta historical region, it was founded in 1927 from the communes of Rodengo and Saiano.

It is home to a Cluniac monastery, the Abbazia di San Nicola (Abbey of St. Nicholas), founded in the mid-11th century.

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