Rodrigo Ponce de León, 4th Duke of Arcos, (2 January 1602 – 1658) was a Grandee of Spain and a Knight of the Order of the Golden Fleece.
He was the son of Luis Ponce de León y Zúñiga (1573-1605), 5th Marquis of Zahara, son of the 3rd Duke of Arcos and of Victoria de Álvarez de Toledo y Colonna.
His younger brother was Luis de Guzmán Ponce de Leon, Governor of the Duchy of Milan.
He married Ana Francisca de Aragón y Córdoba, daughter of Enrique de Aragón, Duke of Segorbe, with whom he had three sons.
[1] As Viceroy of Naples, the Duke of Arcos suppressed a revolt by inhabitants of the city of Naples led by Masaniello but was soon faced with another revolt against Spanish rule, which resulted in the proclamation of the short-lived Neapolitan Republic.