Roff is a town in Pontotoc County, Oklahoma, United States.

26.5% of all households were made up of individuals, and 15.7% had someone living alone who was 65 years of age or older.

The town was named for Joseph T. Roff, a rancher who moved from Texas to the Chickasaw Nation, Indian Territory, in 1871.

Roff and his Choctaw wife and children settled near the present townsite in 1883.

A community developed along the nearby Blue River soon after Roff began leasing his land to whites in 1885.

A subscription school was established there in 1889 and a post office, designated Roff, opened in June 1890.

Other early businesses included a bottling works, a brick plant, and bakeries.

Roff's decline began when crop prices fell during the 1920s and continued through the Great Depression and World War II.

Businesses included a restaurant, an automobile dealership, two gasoline stations with convenience stores, and a housing construction firm.