Describing himself as a "corpse within MPB",[2] his unique musical style which granted him a passionate cult following is characterized by minimalism, repetition and eclecticism, and his writings are permeated by grotesque, shocking and offensive imagery; acerbic allusions to popular culture; metafictional devices; absurdist and surreal scenarios; pessimism; profanity; nihilism; and scatological and black comedy[3] – although he denies that his work is purposefully humorous.

[9][13] After a brief stint as the vocalist of punk rock band Setembro Negro in the mid- to late 1980s,[14] in 1991 he participated as a solo artist in a music festival in Juiz de Fora, Minas Gerais; he won the first-place cash prize with the song "Samba do Skylab", from which he took his stage name, explaining that he considered himself "akin to a space station, picking up different transmissions here and there and fashioning them into a single whole".

It was produced by Robertinho do Recife and spawned which is arguably his most well known song, "Matador de Passarinho", but Skylab was slightly unsatisfied with the final result, saying that it had "too much keyboards" and that he was not too creatively involved with it.

[25] On November 15, 2017, he released the self-titled Skylab EP, which counted with guest appearances by São Paulo-based experimental/noise rock duo Farme&Hixizine and carioca electronica musician Cadu Tenório.

[46] In an April 2023 interview for the website Tenho Mais Discos que Amigos, Skylab has commented on a potential new trilogy of albums following the end of the then-ongoing "Trilogia do Cosmos", entitled "Trilogia do Fim" ("Trilogy of the End"), stating that "it'll probably be [his] final work before [he] can die";[47] volume 1, which was co-written and co-produced alongside Cadu Tenório, was officially announced on November 3, its first seven singles being released in monthly installments starting with "Minha Música"[48][49] and finishing with "Rainha do Mar" on May 17, 2024.

[51] Notwithstanding his statement implying that he planned to end his discography with the "Trilogia do Fim", Skylab later backtracked on his decision, and announced a new studio album on February 15, 2025, with the release of the teaser single "Eu Vou te Dar".

It was recorded during a July 31, 2021 livestream he uploaded to his YouTube channel, celebrating the 30th anniversary of his musical career, and each track of it was taken from one of his respective albums, ranging from his debut Fora da Grei to his most recent release at the time, Os Cosmonautas.

[54] On December 10, 2022, Skylab uploaded to YouTube the single "Juízo Final", a Nelson Cavaquinho cover, featuring Alexandre Kassin [pt], who played the guitar and contributed with the arrangements.

[57] In 2017 he debuted as an actor, portraying a history teacher on the Fabrício Bittar comedy film Como se Tornar o Pior Aluno da Escola, based on Danilo Gentili's eponymous book.

[59] In 2020 he published the collection of political essays Lulismo Selvagem through Kotter Editorial,[60] who also re-issued Debaixo das Rodas de um Automóvel after many years out of print.

[73] In 2016 he took part in the compilation A Música Contra o Golpe, organized by several other left-wing bands and artists in opposition to the impeachment of Dilma Rousseff, contributing with a cover of Gal Costa's "Três da Madrugada".

[75] In mid-2018 Skylab was notoriously engaged in a feud with also Rio de Janeiro-based indie rock band Autoramas, towards which he displays a particular distaste; after posting on his Twitter page that he considered Autoramas "the worst band of all time", they replied disdainfully by saying "at least [they were] professional musicians, with shows all around the year and touring all around the world", finishing by calling Skylab an "amateur artist" and calling him out for supposedly having previously contacted their frontman Gabriel Thomaz to write songs for him.