In 1509/10 he was occupying the post of Master of St. Anthony's Hospital, St Benet Fink in the City of London, but the exact date of his appointment is not known.
[14] In 1475 this Hospital, previously an independent foundation, had been annexed and appropriated to the College of St. George at Windsor Castle, and thus Lupton's appointment as Master was by the king.
[15] In 1527, he established six scholarships to St John's College, Cambridge, to be awarded exclusively to boys from Sedbergh School with a preference for founder's kin[16] - Lupton having had no children himself - and that they be sons of men with "lands truly purchased whose mansions were sufficienty built".
A document held in the archives of St John's records that the scholars were: As per the founder's kin clause, Lupton's relative, William Lupton (1732–1782), attended Sedbergh School and then St John's College, Cambridge before being assistant master at Leeds Grammar School and ordained to pursue a ministry in the Anglican church.
His monumental brass survives at Eton, showing him dressed as a Canon of Windsor wearing a long robe with a cross.
The wolves were canting references to his surname from the Latin Lupus, "a wolf", and Sable, three lilies argent, the same arrangement, is the base part of the arms of Eton College.