He was a seven-time Pro Bowler after playing college football for the Missouri Tigers, where he was a consensus All-American and a first-round draft choice by the Cardinals in 1969.

Roger had ten career interceptions, with seven coming in his senior season, also returning kickoffs and punts.

To finish off an 8–3 season, Wehrli had a decisive interception to help lead the Missouri to a 35–10 victory over the University of Alabama in the Gator Bowl.

Wehrli was a member of the first class of inductees into the Missouri Sports Hall of Fame, located in Springfield.

[2] Although he only played on five winning teams and only went to the playoffs in non-strike years twice, he is considered one of the best cornerbacks in the history of the game.

When inducted into the Pro Football Hall of Fame, he became the second Missouri player to be elected, joining former tight end Kellen Winslow, who was enshrined in 1995.

In 1972 Wehrli was moved to safety by the Cardinals coaching staff where he played alongside Hall of Famer Larry Wilson.

In his first start at the other corner, he broke up two passes and made four tackles as the Cards shut out the Buffalo Bills, 24–0.