It is an analog synthesizer but with digitally controlled oscillators and chorus effects.

[2] Artists who have used the Juno-106 include Jacob Mann, Vince Clarke, Frankie Goes to Hollywood, Chvrches, Leftfield,[4] William Orbit,[5][6] Paul Frick from Tangerine Dream, Underworld, Reel 2 Real, Jam & Spoon, and Vangelis.

[2] The synth's popularity continues to the present day, especially with EDM and artists such as Tame Impala,[9] Daft Punk,[10] Calvin Harris,[11] Armin van Buuren,[12] Mark Ronson,[13] Caribou[14] among many others.

[21] Roland released the Juno-X in 2022, a modern synth featuring digital emulations of the Juno-60 and Juno-106 as well as an additional Juno-X model that features a supersaw waveform, velocity sensitivity and an Alpha-Juno style pitch envelope control.

[25][26] In 2020, Cherry Audio released the DCO-106 plugin, a juiced up version of the Juno-106 which was priced at $39 USD in 2020.