Uniquely for the time, the System 100 didn't "lock in" the oscillators to fixed footages or pitches, allowing greater flexibility for sound design.
The System 100 is still sought-after due to its filter, sequencer and patching capabilities, though the oscillators can be unstable at the lower frequencies, and the keyboard is prone to mis-triggering and double-triggering if not used regularly.
The system was notably used by Mute Records label head Daniel Miller, who helped produce Depeche Mode's A Broken Frame; and by The Human League (MK1 incarnation).
Specifically, the albums Reproduction and Travelogue used a large System 100 (1 x 101, 2 x 102, 2 x 104, 1 x 103) multitracked to provide nearly all the arrangements, including drums and percussion.
The K2 Plan (Shekhar Raj Dhain) used it extensively in a similar vein, multitracked and with the sequencer providing odd syncopations and effects.