The regiment received drafts of French and Polish prisoners of war to replace its losses and in 1810 participated in the British invasion of the Septinsular Republic.

[1] De Roll, who served as colonel, had requested that the British Army release all Swiss prisoners of war to him for incorporation into the regiment but this was not authorised and most of the men were recruited by traditional means from Switzerland, Alsace and Germany.

The regiment was at Minorca in September 1799 and Gibraltar in October 1800 before it was sent, under General Ralph Abercromby to fight French forces in Egypt.

[1] De Roll then appointed Jost Dürler who, having previously served as a lieutenant-colonel, commanded the rearguard of the Swiss during the defence of the Tuileries, as colonel.

[1] Having suffered around 40% casualties in the Egyptian campaign, Roll's Regiment augmented its strength when some French prisoners of war were recruited into its ranks, including at least 45 Poles.

[6] Roll's Regiment took part in the British invasion of the French-controlled Septinsular Republic (the Ionian Islands) in 1810 and was then stationed at Sicily guarding Ferdinand IV of Naples until 1812.