He is Ikerbasque Research Professor at the Donostia International Physics Center (DIPC), as well as co-founder and Chief Scientific Officer of Multiverse Computing.

[8] He also held visiting professorships at CNRS (Toulouse, France) and DIPC and has lectured at the Institute for Pure and Applied Mathematics at UCLA.

[1][19][3][2][20] In 2023, Orus developed an algorithm for executing complex calculations on noisy intermediate scale quantum computers to solve specialized problems like optimization.

[21][22][23] Also in 2023, Orus designed a quantum-enhanced kernel method for image classification, applying quantum artificial intelligence to identify manufacturing defects.

[4][2] In 2014, Orús designed a tensor network algorithm to characterize topologically ordered systems with quantum many-body entanglement.